Product Specialist - Mass Spec Agilent Technologies Santa Clara, California
Description: This talk explores how LC‑MS–based Multi‑Attribute Methods (MAM) enable simultaneous monitoring of critical quality attributes in monoclonal antibodies and increasingly complex bioconjugates such as ADCs and AOCs. It will showcase robust peptide‑mapping and LC/Q‑TOF workflows that quantify both conventional post‑translational modifications and conjugation‑specific features. Practical considerations around method performance, stability indication, and scalability across development and comparability studies will also be highlighted.
Learning Objectives:
LC-MS based MAM workflows support simultaneous monitoring of critical quality attributes in mAbs, ADCs, and AOCs.
Key analytical considerations for extending peptide mapping methods to complex bioconjugates, including conjugation-specific modifications.
Explain practical strategies for implementing MAM workflows to support development, stability studies, and comparability assessments.
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